Radiolab Host Latif Nasser, Biochemist Mandë Holford, Neuroscientist Daniela Schiller join Playwrights Sam Chanse & Lloyd Suh & Science Editor Sophie Bushwick for 2024 EST/Sloan Zoom Event

Top row, from left: Latif Nasser, Mandë Holford, Daniela Schiller

Bottom row, from left: Sam Chanse, Lloyd Suh, Sophie Bushwick

Where do ideas for plays come from? How do you develop a play? How is an EST/Sloan play different?

PLAYWRIGHTS! JOIN US ON TUESDAY, OCTOBER 29, 2024 AT 8:00 PM ON ZOOM FOR THE 2024 EST/SLOAN ARTIST CULTIVATION VIRTUAL EVENT

The EST/Sloan Artist Cultivation Event is the annual far-ranging and free-wheeling discussion among scientists, science writers, and playwrights about science, storytelling, and what makes plays work. This year’s event will be online and is free for any playwright interested in developing a play about science or technology. Registration is required. Once registered, you will receive the event access link in your confirmation email. You can register here.

WHAT MAKES A PLAY ABOUT SCIENCE GREAT?

“To stimulate artists to create credible and compelling work exploring the worlds of science and technology and to challenge the existing stereotypes of scientists and engineers in the popular imagination.”—this has been the mission of The Ensemble Studio Theatre/Alfred P. Sloan Foundation Science & Technology Project (EST/Sloan Project, for short) for the past 25 years. Over that time the EST/Sloan Project has awarded more than $3 million in grants to some 300 playwrights and theater companies. More than 150 productions of EST/Sloan-developed plays have been mounted nationwide. Commissions range from $5,000 to $10,000.

Applications for this year’s EST/Sloan commissions are currently open and will be accepted through November 15, 2024. You can view previous commission recipients on the EST/Sloan webpage.

Two related events culminate each EST/Sloan season:

1) The First Light Festival is a months-long series of readings and workshops that showcase plays in development, and is currently in progress through December 12.

2) A full mainstage production of at least one work every season. Recent mainstage productions have included Franklinland by Lloyd Suh about William and Ben Franklin and experiments scientific and otherwise (currently running through November 3), Las Borinqueñas (2024) by Nelson Diaz-Marcano about the birth control pill trials in Puerto Rico in the 1950s, Smart (2023) by Mary Elizabeth Hamilton about AI technology and trust, what you are now (2022) by Sam Chanse about memory and trauma, Behind the Sheet (2019) by Charly Evon Simpson about how American gynecology began with experiments on slaves (a NY Times Critic’s Pick), BUMP by Chiara Atik (2018) on pregnancy and childbirth, SPILL (2017) by Leigh Fondakowski on the Deepwater Horizon disaster, Boy (2016) by Anna Ziegler on sexual identity, Please Continue (2016) by Frank Basloe on Stanley Milgram’s obedience experiments, Informed Consent (2015) by Deborah Zoe Laufer on scientific research and Alzheimer’s, Fast Company (2014) by Carla Ching on game theory and confidence games, Isaac’s Eye (2013) by Lucas Hnath on scientific method and rivalry, and Headstrong (2012) by Patrick Link on sports and concussions.

This year's Artist Cultivation Event panelists include:

Sam Chanse

Sam Chanse’s plays include What you are now (Ensemble Studio Theatre & The Civilians), Disturbance Specialist (The Public Theater & National Asian American Theatre Company’s Out of Time), Trigger (Lark Venturous Fellowship), Fruiting Bodies (Ma-Yi Theater), and Monument, or Four Sisters (A Sloth Play) (Magic Theatre). A resident playwright of New Dramatists, her work has also been developed with Ars Nova (P.S.), Cherry Lane (The Opportunities of Extinction), Playwrights’ Realm (The Other Instinct), New York Stage & Film, Boston Court, the Ojai Playwrights’ Conference, and is published by Kaya Press (Lydia’s Funeral Video) and TCG (The Kilroys List). She is a recipient of a 2024 Bret Adams & Paul Reisch Foundation Vivace Award with collaborators MILCK and AG, and is currently developing a new musical, The Family Album, as a commission of La Jolla Playhouse. Other commissions include EST/Sloan Project, NAATCO, Ars Nova, Workshop Theater, the University of Rochester, and the San Francisco Arts Commission. A former fellow of MacDowell, the Lark Venturous Theater Fund, Cherry Lane, Sundance Theatre Institute, and Playwrights Realm, she is a member of Dramatists Guild and WGAW, and wrote on three seasons of ABC’s The Good Doctor. Proud alum: Ars Nova’s Play Group, Civilians R&D Group, and the Ma-Yi Writers Lab.

Dr. Mandë Holford  Photo Credit: DFinnin_AMNH

Mandë Holford is a Professor in Chemistry at Hunter College and CUNY-Graduate Center, with scientific appointments at The American Museum of Natural History and Weill Cornell Medicine. The Holford Laboratory of Chemical and Biological Diversity demonstrates the scientific path from mollusks to medicine - examining how venoms evolved, developed, and function over time, and how we can use this knowledge as a roadmap for discovering and characterizing peptide natural products with therapeutic potential. She is particularly interested in using venoms and venom peptides to study rapidly evolving genes and to develop invertebrate venom gland model systems that can be genetically manipulated to advance discoveries in novel gene regulation, expression, and function. Her work combines scientific research, education and diplomacy to understand the extraordinary marine biodiversity on our planet and transform this knowledge for the benefit of human and planetary health. She is cofounder of Killer Snails, LLC, an award winning EdTech company that uses tabletop, digital, and XR games as a conduit to advance scientific learning in K-12 classrooms. 

Latif Nasser

Latif Nasser is co-host of the award-winning WNYC Studios show Radiolab, where he has reported stories on everything from snowflake photography to medieval robots to a polar bear who liked to have sex with grizzly bears. He also hosted the award-winning miniseries The Other Latif, about his Moroccan namesake who was Detainee 244 at Guantanamo Bay. In addition to his work in audio, Latif is the host and executive producer of the Netflix science documentary series, Connected.  He has also given two TED talks, and written for the Boston Globe Ideas section. He has a PhD from Harvard's History of Science department.

Dr. Daniela Schiller

Daniela Schiller is a Professor in the Department of Psychiatry, the Nash Family Department of Neuroscience, and the Friedman Brain Institute at the Icahn School of Medicine at Mount Sinai. Her research is focused on how the brain represents and modifies emotional memories. Schiller got her PhD in Tel Aviv University where she developed a laboratory model for negative symptoms of schizophrenia. She then continued to do a postdoctoral fellowship at New York University where she examined methods for emotional memory modification in the human brain. Schiller joined Mount Sinai in 2010 and has been directing the affective neuroscience laboratory since. Her lab has delineated the neural computations of threat learning, how the brain modifies emotional memories using imagination, and the dynamic tracking of affective states and social relationships. Schiller’s work has been published in numerous scholarly journals, including Nature, Neuron, Nature Neuroscience, and the Proceedings of the National Academy of Sciences. She is a Fulbright Fellow and a Kavli Frontiers of Science Fellow, and has been the recipient of many awards, including the New York Academy of Sciences’ Blavatnik Award, and the Klingenstein-Simons Fellowship Award in the Neurosciences. 

Lloyd Suh

Lloyd Suh is the author of The Chinese Lady (Ma-Yi at The Public Theater), Bina's Six Apples (Alliance Theatre and Children's Theatre Company), Charles Francis Chan Jr.'s Exotic Oriental Murder Mystery, The Wong Kids in the Secret of the Space Chupacabra Go!, Franklinland, and more, including The Heart Sellers, (Milwaukee Rep). His play The Far Country (Atlantic Theatre) was a finalist for the 2023 Pulitzer Prize for Drama. His work has been produced at theaters across the country, including Ensemble Studio Theatre, Magic Theatre, National Asian American Theatre Company, Denver Center, ArtsEmerson, Long Wharf and others, and internationally at the Cultural Center of the Philippines and with PCPA at the Guerilla Theatre in Seoul, Korea. Awards include the Guggenheim Fellowship, Herb Alpert Award, Horton Foote Prize, and Helen Merrill Award. He was elected in 2016 to the Dramatists Guild Council. Starting in 2015, he has been a member of the Dramatists Guild Council. He joined The Lark as the Director of Artistic Programs in 2011. From 2005 to 2010 he was the Artistic Director of Second Generation and Co-Director of the Ma-Yi Writers Lab. He is a member of Ensemble Studio Theatre and an alum of Youngblood and the Soho Rep Writer Director Lab.

About the Moderator

Sophie Bushwick

Sophie Bushwick is a science and technology journalist based in New York City and is currently working as senior news editor at New Scientist. She has more than a decade of experience as a writer and editor at outlets including Scientific American, Popular Science, Discover Magazine and Gizmodo, and she continues to make regular appearances on Science Friday. Her work spans digital and print, podcasts and radio, TV news and TikTok.

Poet Pichchenda Bao, Neuroscientist Heather Berlin, Artist Daveth Cheth, Designer Davey Chhoeun, and Chef Chinchakriya Un join Dramaturg Soriya Chum to discuss the many sides of what you are now

From left, Pichchenda Bao, Heather Berlin, Daveth Cheth, Davey Chhoeun, Chinchakriya Un, Soriya Chum

On April 2, following the 2:00 PM matinee performance of what you are now, the powerful new drama by Sam Chanse, everyone is encouraged to stay for a talkback about the historical, cultural, and scientific context of the play, as well as the many issues it addresses, including how trauma gets passed from one generation to another, Cambodian American life in the U.S., and what happens in the brain when we form memories and create art. Dramaturg Soriya Chum will moderate the discussion with neuroscientist Heather Berlin, poet Pichchenda Bao, artist and activist Daveth Cheth, designer Davey Chhoeun, and chef Chinchakriya Un.

what you are now asks what if our memories aren’t fixed, but change each time we recall the past? This world premiere by Sam Chanse is a thrillingly insightful new play that asks the audience to move through the shifting dance between the past and present, and to consider how with new understanding we might change “who you were then” to “what you are now.”

what you are now is this year’s mainstage production of the EST/Sloan Project, EST’s partnership with the Alfred P. Sloan Foundation to develop new plays “exploring the worlds of science and technology,” an initiative now in its twenty-third year, and is being co-presented with The Civilians, a theater group dedicated to investigative theater, projects created through field research, community collaborations, and other methods of in-depth inquiry.

About the Panelists

Pichchenda Bao

Pichchenda Bao is a poet born in Cambodia at the end of the Khmer Rouge regime. She came with her parents to the United States as refugees in the 1980s, and now she lives, writes and raises her children in New York City. Her work delves into the urgencies and uncertainties of post-war and post-genocide survival and resilience, generational tension, motherhood, and feminism. Her honors include a Pushcart Prize nomination, an Emerging Writer Fellowship from Aspen Words, a grant from Queens Council on the Arts, a residency from Bethany Arts Community, and an invitation to the Kundiman writers retreat as a poetry fellow.

Dr. Heather Berlin

Dr. Heather Berlin is a neuroscientist and Associate Clinical Professor of Psychiatry and Neuroscience at the Icahn School of Medicine at Mount Sinai in NY. She explores the neural basis of impulsive and compulsive psychiatric and neurological disorders with the aim of developing novel treatments. She is also interested in the brain basis of consciousness, dynamic unconscious processes, and creativity.  Berlin is a passionate science communicator and a committee member of the National Academy of Sciences and the American Association for the Advancement of Science (AAAS). She’s hosted series on PBS and the Discovery Channel and makes regular appearances on StarTalk with Neil DeGrasse Tyson, BBC, History Channel, Netflix, National Geographic, and TEDx, and was featured in the documentary film Bill Nye: Science Guy. Dr. Berlin also co-wrote and starred in the critically acclaimed off-Broadway show, Off the Top, about the neuroscience of improvisation, and the Edinburgh Fringe Festival show, Impulse Control.  Berlin received her doctorate from the University of Oxford, and Master of Public Health from Harvard University, and trained in clinical neuropsychology at Weill Cornell Medicine’s Department of Neurological Surgery. She is a visiting scholar at the New York Psychoanalytic Society and Institute, and was a Visiting Professor at Vassar College, the Swiss Federal Institute of Technology/University of Zurich, and The Hebrew University of Jerusalem.

Daveth Cheth

Daveth Cheth is the founder, writer, and visionary behind Khmer Identity, a platform honoring Khmer legacies and contemporary Khmer voices. Born in Cambodia, Daveth immigrated to Lynn, Massachusetts when he was nine. A queer, non-binary Cambodian artist and activist, Daveth explores the  mediums of art, dance, and spoken word by focusing his work around queer visibility and Cambodian heritage and culture. A native Khmer speaker, Daveth teaches online classes in Khmer through Khmer Identity.

Davey Chhoeun

Davey Chhoeun is co-founder of Khmer Identify. The youngest daughter of four, and the only one born in the U.S., Davey was born and raised in Lynn, Massachusetts, where her family immigrated from Cambodia in 1988. Davey aspires to share her creative lens with her community and the world through apparel design and many personal hobbies. She graduated from Massachusetts College of Art and Design with a BFA in Fashion Design. Currently, she is a designer at a manufacturing company based in Boston. In 2020, at the beginning of the pandemic, she collaborated with Daveth Cheth to create an exhibition to share their mutual heritage with the world. This became Khmer Identity.

Chinchakriya Un

Chinchakriya Un is the chef and owner of Kreung Cambodia.  Kreung is a project that highlights her family’s recipes and new inspired dishes that she creates. Kreung is a traveling pop up with roots in Brooklyn, NY. Chinchakriya’s goals are to raise money to buy a tractor for her family in Cambodia, create a residency for artists, connect with the Cambodian diaspora around the world, and to document her family’s stories from the past and present to include in a cookbook. She was born in a refugee camp, moved to Massachusetts and grew up in a neighborhood with other immigrant families, predominately Puerto Rican, Dominican, and Cape Verdeans, and attended a predominately white school. Chinchakriya has found  that connecting with her elders and Khmer folks in the diaspora is a way that she continues to grow her understanding about the Khmer culture. She hopes that Kreung can exist as a platform for other young aspiring chefs to showcase their creations.

About the Moderator

Soriya K. Chum

Soriya K. Chum is a Cambodian American writer, dramaturg, and project manager working in the fields of arts and culture and book publishing. He currently produces consumer engagement events and programs for the Random House division of Penguin Random House. Previously, he has held roles at the flagship branch of The New York Public Library, Theatre for a New Audience, and the Asian American Arts Alliance. As a dramaturg, he specializes in providing support to scripted projects that focus on the lives of contemporary immigrants and refugees, particularly intergenerational stories that center the perspectives and experiences of Cambodian Americans.

what you are now began previews on March 10 and runs through April 3 at EST. You can purchase tickets here.

Community Organizers Sothea Chiemruom, Sanary Phen, and Thida Virak join Neuroscientist Daniela Schiller and Editor Laura Ly to discuss inherited trauma, Cambodian American life, and what you are now

From left, Sothea Chiemruom, Sanary Phen, Thida Virak, Daniela Schiller, and Laura Ly.

On March 26, following the 2:00 PM matinee performance of what you are now, the powerful new drama by Sam Chanse, everyone is encouraged to stay for a talkback about the historical, cultural, and scientific context of the play, as well as the many issues it addresses, including how the brain forms memories, Cambodian American life in the U.S., and the neuroscience of inherited trauma. Journalist-editor Laura Ly will moderate the discussion with neuroscientist Daniela Schiller, and community organizers Sothea Chiemruom, Sanary Phen, and Thida Virak.

what you are now asks what if our memories aren’t fixed, but change each time we recall the past? This world premiere by Sam Chanse is a thrillingly insightful new play that asks the audience to move through the shifting dance between the past and present, and to consider how with new understanding we might change “who you were then” to “what you are now.”

what you are now is this year’s mainstage production of the EST/Sloan Project, EST’s partnership with the Alfred P. Sloan Foundation to develop new plays “exploring the worlds of science and technology,” an initiative now in its twenty-third year, and is being co-presented with The Civilians, a theater group dedicated to investigative theater, projects created through field research, community collaborations, and other methods of in-depth inquiry.

About the Panelists

Sothea Chiemruom

Sothea Chiemruom is the Executive Director at CMAA-the Cambodian Mutual Assistance Association in Lowell, MA. He has over 25 years of experience in day-to-day program operations, administration, management, reporting, and ongoing work in advocacy, and public relations. CMAA provides services for not only Khmer but vulnerable individuals who need support with everyday challenges. Throughout his career, Sothea has engaged youth, the elderly, and the underrepresented and promoted programs that serve them. A strong proponent for the education of immigrants and refugees, he promotes leadership training, economic development, and civic participation. He actively supports the empowerment and self-sufficiency of community members. He serves as vice-chairperson of the Affordable Housing Trust in the Town of Tyngsborough, MA.  Sothea has participated at NeighborWorks Training Institute, a  leadership program. A refugee from Cambodia, he has lived and worked in Boston and Lowell. He currently lives in Tyngsbo, MA with his wife, Bora, and their children. He enjoys the outdoors and gardening.

Sanary Phen

Poet, writer and storyteller, Sanary Phen was born in a refugee camp in Thailand during the Khmer Rouge era in Cambodia. She and her family emigrated to the United States in 1981 and resettled in Lowell, MA, which has been her home for more than 35 years. Sanary has a deep love and appreciation for the community and takes pride in giving back to the city and its people. She has over 15 years of experience in social work in the nonprofit sector and is currently working for Coalition for a Better Acre as their Workforce Development Coordinator. Sanary is also a freelance writer for the Lowell Sun and a dedicated volunteer with the Cambodian American Literary Arts Association.

Dr. Daniela Schiller

Dr. Daniela Schiller is a Professor in the Department of Psychiatry, the Nash Family Department of Neuroscience, and the Friedman Brain Institute at the Icahn School of Medicine at Mount Sinai. Her research is focused on how the brain represents and modifies emotional memories. Schiller got her PhD in Tel Aviv University where she developed a laboratory model for negative symptoms of schizophrenia. She then continued to do a postdoctoral fellowship at New York University where she examined methods for emotional memory modification in the human brain. Schiller joined Mount Sinai in 2010 and has been directing the affective neuroscience laboratory since. Her lab has delineated the neural computations of threat learning, how the brain modifies emotional memories using imagination, and the dynamic tracking of affective states and social relationships. Schiller’s work has been published in numerous scholarly journals, including Nature, Neuron, Nature Neuroscience, and the Proceedings of the National Academy of Sciences. She is a Fulbright Fellow and a Kavli Frontiers of Science Fellow, and has been the recipient of many awards, including the New York Academy of Sciences’ Blavatnik Award, and the Klingenstein-Simons Fellowship Award in the Neurosciences. 

Thida Virak

Thida Virak is the Director of Social Services & Advocacy at Mekong NYC and was previously Lead Organizer for Mekong NYC for ten years. Born in Phnom Penh, Cambodia, Thida immigrated to the Bronx, where she began her work in the community as a volunteer. Shortly after Mekong NYC was founded in 2011, she joined as a part-time organizer and quickly helped build Mekong NYC’s community base, and was promoted to Director of Social Services & Advocacy in October 2021. Mekong NYC is a social justice organization that brings dignity and value to the lives of Southeast Asians in the Bronx and throughout New York City. As an organizer, advocate, interpreter and translator, freedom fighter, and mother, she exemplifies the spirit of social justice and advocacy. Her work explores identities, culture, collective healing, mutual supports, and community building, and deepens Mekong NYC’s campaigns for health justice, mental health justice, and the end of deportation in the Southeast Asian community. She also serves as a delegate in various coalitions, like the Bronx-Wide People’s Platform. Thida attended John Jay College of Criminal Justice and Borough of Manhattan Community College, and completed ANHD’s Center for Community Leadership Organizing program.

About the Moderator

Laura Ly

Laura Ly is an Emmy-nominated journalist and editor based in New York City. In her time with CNN, she has also worked in Hong Kong and Atlanta. She currently covers breaking news across the northeast United States. She is the daughter of Khmer refugees from Battambang and Takeo provinces.  Ly is a longtime Board Member of the Cambodian American Literary Arts Association and also serves on their literary magazine committee. Each year, the organization publishes the “Stilt House” zine, a showcase dedicated to celebrating the work of artists in the Cambodian diaspora. Ly is originally from Connecticut and is a graduate of Columbia University. In her free time, she enjoys travel writing, biking, playing badminton, and attempting to cook Khmer food.

what you are now began previews on March 10 and runs through April 3 at EST. You can purchase tickets here.

Actor Robert Lee Leng, Neuroscientist Daniela Schiller, Poet Sokunthary Svay and Actor Sophia Skiles to discuss how we form memories, Cambodian American culture, inherited trauma and what you are now

From left, Robert Lee Leng, Daniela Schiller, Sokunthary Svay, Sophia Skiles

On March 19, following the 2:00 PM matinee performance of what you are now, the compelling new drama by Sam Chanse, everyone is encouraged to stay for a talkback about the historical, cultural, and scientific context of the play, as well as the many issues it addresses, including how the brain forms memories, Cambodian American memory work, and the neuroscience of inherited trauma. Actor-teacher Sophia Skiles will moderate the discussion with Cambodian-Chinese American actor Robert Lee Leng (Darany in the play), neuroscientist Daniela Schiller, and Cambodian American poet-scholar-librettist Sokunthary Svay.

what you are now asks what if our memories aren’t fixed, but change each time we recall the past? This world premiere by Sam Chanse is a thrillingly insightful new play that asks the audience to move through the shifting dance between the past and present, and to consider how with new understanding we might change “who you were then” to “what you are now.”

what you are now is this year’s mainstage production of the EST/Sloan Project, EST’s partnership with the Alfred P. Sloan Foundation to develop new plays “exploring the worlds of science and technology,” an initiative now in its twenty-third year, and is being co-presented with The Civilians, a theater group dedicated to investigative theater, projects created through field research, community collaborations, and other methods of in-depth inquiry.

About the Panelists

Robert Lee Leng

Robert Lee Leng (Darany in the play) I am a first generation Cambodian-Chinese American/Artist. To be an artist during the Khmer Rouge regime meant immediate death; but we survived; we are surviving. We are a very expansive, complex, eclectic, and lit community of people.  I love us. Read Afterparties by Anthony Veasna So; Read Unsettled: Cambodian Refugees in the New York City Hyperghetto by Eric Tang; Stream music by $tupid Young, VBO, VannDa; follow @Khmer.identity on Instagram. Reach out, donate and show support to CMAA Lowell and Mekong NYC.

Dr. Daniela Schiller

Dr. Daniela Schiller is a Professor in the Department of Psychiatry, the Nash Family Department of Neuroscience, and the Friedman Brain Institute at the Icahn School of Medicine at Mount Sinai. Her research is focused on how the brain represents and modifies emotional memories. Schiller got her PhD in Tel Aviv University where she developed a laboratory model for negative symptoms of schizophrenia. She then continued to do a postdoctoral fellowship at New York University where she examined methods for emotional memory modification in the human brain. Schiller joined Mount Sinai in 2010 and has been directing the affective neuroscience laboratory since. Her lab has delineated the neural computations of threat learning, how the brain modifies emotional memories using imagination, and the dynamic tracking of affective states and social relationships. Schiller’s work has been published in numerous scholarly journals, including Nature, Neuron, Nature Neuroscience, and the Proceedings of the National Academy of Sciences. She is a Fulbright Fellow and a Kavli Frontiers of Science Fellow, and has been the recipient of many awards, including the New York Academy of Sciences’ Blavatnik Award, and the Klingenstein-Simons Fellowship Award in the Neurosciences. 

Sokunthary Svay

Sokunthary Svay was born in a refugee camp in Thailand shortly after her parents fled Cambodia following the fall of the Khmer Rouge. They resettled in the Bronx, where she grew up. She is a founding member of the Cambodian American Literary Arts Association (CALAA), and has received fellowships from the American Opera Project, Poets House, Willow Books, and CUNY, as well as commissions from Washington National Opera, White Snake Project, and ISSUE Project Room. Her first book, Apsara in New York, was published in 2017. Her first opera, Woman of Letters, premiered at the Kennedy Center in January 2020. Her second opera,Chhlong Tonle, funded by the OPERA American IDEA grant, premieres in March 2022. She is currently pursuing her PhD in English at the CUNY Graduate Center.

About the Moderator

Sophia Skiles

Sophia Skiles (she/her) is a theater actor, a teacher of acting, facilitator, and citizen—purposefully blurring, disrupting, and bridging the boundaries of the stage, the classroom, and the public.  She has performed in productions directed by Michael Kahn, May Adrales, Chay Yew, Ralph Peña, Andrei Serban, Mary Zimmerman, Richard Foreman, and David Herskovits, among others - in venues throughout New York City, and across the United States and Europe.  Sophia is Associate Professor of the Practice and Head of Acting of the Brown/Trinity MFA program and a former twice-elected Trustee of the New Paltz Central School District Board of Education.  She was a member of the 2016 artEquity National Facilitator training cohort and the 2021 artEquity BIPOC Leadership Circle. 

what you are now began previews on March 10 and runs through April 3 at EST. You can purchase tickets here.

A Note on the Neuroscience Behind what you are now

The EST/Sloan Project is committed to “challenge and broaden the public’s understanding of science and technology and their impact on our lives.” In that spirit, we offer this essay on the neuroscience behind what you are now by Sam Chanse, the 2022 EST/Sloan mainstage production. what you are now began previews on March 10 and runs through April 3. You can purchase tickets here.

The Neuroscience Behind what you are now

By Rich Kelley, Science Press Liaison

“Memory is a marvelous device, a means of transporting ourselves to earlier times. We can go back a moment, or most of a life. But as we all know, it’s not perfect, and is certainly not literal. It’s a reconstruction of facts and experiences on the basis of the way they were stored, not as they actually occurred. And it’s a reconstruction by a  brain that is different from the one that formed the  memory.” —Joseph LeDoux

A quick review of the metaphors we have used for memory reveals how far we have come—and how inadequate we are at describing it: from wax tablet to library to labyrinth to enchanted loom to switchboard to network to leaky bucket to computer program to hologram. From a scientific standpoint, what has changed our thinking about memory has usually come from an experiment. WHAT YOU ARE NOW refers to several significant experiments in the history of neuroscience. We thought you might find this background information on some of them interesting.

Ivan Pavlov (1849‒1936) was a Russian physiologist best known for inventing what has come to be known as “classical conditioning.” To study the physiology of the digestive system, Pavlov invented surgical procedures to create fistulas and gastric pouches on unanesthetized dogs so that he could repeat experiments for months and measure secretions outside the body. During his research Pavlov noticed that the dogs salivated when they saw the person who fed them. This led to his famous experiment: if he played a sound—usually on a metronome, not a bell—just when the food was put in the dog’s mouth, the dog would salivate at the sound, even when the food did not follow. This association turned a previously neutral stimulus—the tone—into a “conditioned” stimulus that generated a “conditioned” response—the salivating. Pavlov called the saliva thus generated “psychic secretions.” The power of the stimuli depended on conditions. If the tone was sounded repeatedly without the dog being fed, the salivating would decrease and eventually stop completely.

One of Pavlov's dogs with a surgically implanted cannula to measure salivation, preserved in the Pavlov Museum in Ryazan, Russia.

American behavioral psychologists favored Pavlov’s procedure because it removed any question of will, subjective experience, or consciousness from their experiments. Yet Pavlov himself never denied the inner life of his experimental animals. As Daniel Todes notes in his biography of Pavlov, “[Pavlov} identified them as heroes and cowards, intelligent and obtuse, independent and compliant, sociable and aloof, freedom fighters and narrow pragmatists.”

Eric Kandel (1929‒ ) is an Austrian-born American medical doctor, psychiatrist, neuroscientist, and professor of biochemistry who won the Nobel Prize in Physiology and Medicine in 2000 for his work on the physiological basis of memory storage in neurons. Kandel is perhaps best known for his insight that learning processes are similar among all life forms and that he could more easily study what changes occur in the synaptic connections between neurons during learning and memory storage by electrophysical analysis of an invertebrate as simple as a sea slug. He published his initial findings in 1963 and over the next twenty years his work in molecular neural science led to several remarkable findings, including that short-term memory involved functional changes in existing synapses but long-term memory involves a change in the number of synaptic connections.

A mouse in a glass container partially filled with water, as part of a forced-swimming test. The use of forced swimming tests is criticized by animal rights groups, notably PETA. (Photo: TaoPan CC3.0)

Learned safety in mice. The play refers to one of Kandel’s experiments with Daniela D. Pollak in which they conditioned mice to feel safe in stressful situations. Kandel called this conditioned inhibition of fear “learned safety.” For fear conditioning they associated an auditory tone with a shock to the mouse’s foot. For safety conditioning, the tone was not followed by a shock. The safety conditioned mice learned to associate the tone with the absence of danger and showed less anxiety, The mice were then given a stress test and put into a pool of water for a swim test. As Kandel explained, “In this seemingly desperate situation—where the mice have no option to escape from the water—they start to show signs of behavioral despair that are ameliorated by antidepressant medications. We found that the mice trained for safety could overcome their sense of hopelessness in the swim test.”

Memory reconsolidation. Memories evolve over time and “consolidation” and “reconsolidation” have come to describe the “two lives” memories have after the initial coding of new information. Consolidation refers to the extended period after learning when new information gets “fixed” at a cellular level and interleaved with existing memories. Much of consolidation is now thought to occur during sleep. Reconsolidation describes the process in which a newly consolidated memory gets modified as it is reactivated. In 2000 neuroscientists Karim Nader, Glenn E. Schafe and Joseph E. LeDoux performed an experiment to test whether it is possible to extinguish a “new memory” so that it never becomes a long-term memory. Current models of learning at the time proposed that new proteins need to be produced for recent experiences to be encoded into long-term memory. In the experiment, rats were conditioned to fear a tone by being given a foot shock. When they heard the tone, they froze into immobility. Twenty-four hours later, the rats were played the tone but given an infusion of anisomycin, a drug that inhibits protein synthesis, into the amygdala. Twenty-four hours later, when the rats which had been given the drug were played the tone, they didn’t freeze. They had lost the memory of the conditioning. This group was tested for up to 14 days and still had no memory of the conditioned response. A test group was given anisomycin without the tone being played. Twenty-four hours later, when they were played the tone, they still froze. In order for the conditioned response to be extinguished, the memory had to be reactivated—the tone had to be played—for the drug to interfere with memory retrieval.

A diagram representing a common understanding of memory systems (Image: Erich Parker)

Extinguishing traumatic memories. Drugs had been used successfully to remove traumatic memories but neuroscientist Daniela Schiller wondered if a non-invasive behavioral technique could be used instead. In 2010 she used classical conditioning to train 65 people to fear a colored square by associating it with a shock. Twenty four hours later, the sight of the square alone induced a fearful reaction in all of them. Schiller then divided them into three groups and presented the squares to one group many more times without a shock. Because this extinction process began within ten minutes of having their memory reactivated, the members of this group completely forgot their fear. A second group, which did not begin the extinction process until six hours after they were shown the squares, did not lose their fear. The experiment demonstrated that memories can be changed behaviorally and that interfering with memory reconsolidation can be effective but is very time sensitive. As Schiller commented in Michael Specter’s profile of her in The New Yorker, her work led her to realize that memory is “what you are now, not what you think you were in the past. When you change the story you created, you change your life.”

A Note on the Historical and Cultural Context of what you are now

The EST/Sloan Project is committed to “challenge and broaden the public’s understanding of science and technology and their impact on our lives.” In that spirit, we offer this essay on the historical and cultural context of what you are now by Sam Chanse, the 2022 EST/Sloan mainstage production. what you are now began previews on March 10 and runs through April 3. You can purchase tickets here.

Passing on the Uncanny

by Soriya K. Chum, Dramaturg

Pia is a neuroscientist whose academic research is intensely enmeshed with the personal. Her scientific investigations concern “fear memories;” her mother is a survivor of the Cambodian genocide. As Pia looks at the long road ahead of possibly breaking into her field with a proposal to rid the brain of traumatic memories, she wrestles with the omnipresence of her own family’s uncanny memories—their capacity to terrorize her mother at night, to induce in their home a stultifying silence, which Pia helps to maintain as a way of coping.

Memory is an intimate process. The experience of a specific memory is palpable not only to loved ones who remember, but also to those who share space intimately with them—so that family, too, can be immersed, by extension, in the pleasure, grief, or violence of a recollection we may not exactly call their own. The reach of memory is powerful, with a magnitude that in some cases is felt across generations, and for a community like Pia’s that once endured a massively traumatic event, their interdependent behaviors of remembrance can either inhibit or change the course of the group’s collective development.

From 1975 to 1979, a communist group known as the Khmer Rouge controlled Cambodia, enacting radical social, economic, and cultural reforms throughout the country. In the group’s pursuit of an agrarian utopia, they expelled entire urban populations and moved them to remote rural provinces where they worked in labor camps. The Khmer Rouge purported that the citizens of this new, classless system would work the land together and live off of it, equally. In the propagation of their doctrine, they sought to re-educate the public on the party’s values and to root out all dissent by punishing alleged loyalists of the former regime. As their paranoia intensified, the Khmer Rouge grew rampantly murderous, targeting intellectuals, capitalists, foreigners, ethnic minorities, and artists. As a result of their totalitarian reign, an estimated 2.5 million people died of execution, starvation, and disease. Those who survived, like Pia’s mother, fled to refugee camps in Thailand—few with families left intact, some alone, all shaped forever by a deeply formative past.

My mother is a survivor of the Cambodian genocide. She evades questions still today about the losses she suffered. When I was a child, she would prepare dishes for our ancestors during the Cambodian New Year as a ritual expression of holding their hunger in the family’s memory. We’d patiently wait for our ancestors to eat first before lifting our forks. I’d crouch on the floor before a festive table presented with ample platters of roasted duck, oily noodles, pickled greens, and sour soup, while clasping sticks of champak incense in silent prayer, sending blessings of peace and comfort to them. My eyes would study the empty chairs, and I imagined I could draw into the seats my ancestors’ silhouettes with the rising, sweet smoke that escaped my hot fingers. I wondered if they could see me too—see us, the living, and how we struggled. I’d blush from the guilt of divining their tired eyes on me.

In what you are now, there is a scene in which Pia’s brother Darany makes a similar ancestral offering. He asserts, “Someone should be feeding us knowhatI’msayin / give us food to ease our suffering.” Embedded within his sentiment is a powerful question of what nourishment is given to people who haven’t passed, but who live on to bear difficult legacies. Darany’s assertion is an interesting counter-proposal to the survivor narrative that tends to centralize the memorialization of atrocious pasts. It is a suggestion that gently shifts our preoccupation with what happened, who we lost, and how we barely survived, to the untidy business of those living today, of nurturing present and future generations after the fact. 

In the eighties, nearly 160,000 Cambodians migrated to the United States as refugees. Planning for their arrival, the federal government assessed cities that could equip the newly arrived with low-wage and low-skill jobs and affordable housing. The majority of Cambodians resettled in communities with pre-existing, high rates of poverty and crime. In the play, Pia’s family migrated to Lowell, Massachusetts, home to the second largest Cambodian community in America. Challenged by the stresses of resettlement—securing a job, learning a language, and adapting to new norms—while burdened with the anguish of having fled genocide, Cambodians found their hard start exacerbated by their placement in distressed areas. From their precarious point of inception in the States, a line can be drawn to many of the contemporary problems faced by Cambodian Americans decades later, including deportation, gang-related violence, underemployment, and mental health conditions. 

In the last twenty years, we’ve seen tremendous advancements in research dedicated to helping us better understand the biological dimensions of trauma. Scientists now know that the posttraumatic stress individuals experience may be owed to changes to gene regions in the brain responsible for processing fearful stimuli. A person living with PTSD then, who shows signs of hypervigilance, reactivity, or avoidance, may be exhibiting these tendencies because of a past traumatic event that distinctly altered their DNA. These genetic changes extend beyond the life of the individual, branching out to the lives of their children and their children’s children, so that patterns of trauma are heritable down the bloodline. 

To stop these effects, Pia is exploring through her research the viability of an intervention that could selectively target and blunt fear memories, so that typical triggers become more like reminders, unimbued of their painful associations. Though a pathway to implementing treatment models and therapies lags behind the research in her field, Pia’s belief in science and its potential to heal is persuasive, and there is, of course, her double-fold experience (as both a scientist and the daughter of a genocide survivor), which is a factor in our bet on her. The dramatic irony of Pia’s mission is how much skin she has in the game. We cheer her on when she perceives connections between her personal life and career with the clarity of an expert witness; and we cringe with compassion when she barrels full-steam ahead in her research with the unchecked zeal of a grief tourist, and forgets herself—her close orientation to the work at hand. 

On a family trip to Cambodia in 2016, I insisted we visit the Tuol Sleng Genocide Museum in Phnom Penh. The building once was a secondary school the Khmer Rouge repurposed as S-21, a prison camp and execution center. Now a museum, it displays the photographs of inmates, their discarded clothes, instruments of torture, and dusty chalkboards that spell of the place’s bygone innocence. In the main artery of the museum, my mother and I came to a large map on a free-standing wall. I took her hand to it. I asked her to trace her journey from Phnom Penh to labor camp to refugee camp for me. Confusion riddled her finger—starting, then stopping, falling, and breaking away from the map. In my abstract way of seeing back with her and urgently correcting the record, hovering over this map, a shade of disappointment rose in me for her failure to remember. My mother then turned and pointed to the open museum door, which looked to a sunlit courtyard lined with swaying palm trees, and she uttered just over the sound of a motorcycle zizzing by that her sister whom she loved lived once two blocks from where we stood. 

 For a scopic regime that deliberately annihilated the social foundation of a society by splitting up sisters, seeding distrust among brothers, rearranging marriages, and orphaning children, the most defiant act for Cambodians today against the perpetrators is keeping our families together. Like Pia’s family, it is a path of trial and error, closing the distance, and putting voice into the gulf of silence.  

Radiolab Host Jad Abumrad, Microbiologist Karine Gibbs, and Biochemist Mandë Holford join Playwrights Sam Chanse and Lucas Hnath at the 2021 EST/Sloan Artist Cultivation Event on December 2

From left: Jad Abumrad, Sam Chanse, Karine Gibbs, Lucas Hnath, Mandë Holford

WHAT MAKES A GREAT PLAY ABOUT SCIENCE?

“To stimulate artists to create credible and compelling work exploring the worlds of science and technology and to challenge the existing stereotypes of scientists and engineers in the popular imagination.”—this has been the mission of The Ensemble Studio Theatre/Alfred P. Sloan Foundation Science & Technology Project (EST/Sloan Project, for short) for the past 22 years. Over that time the EST/Sloan Project has awarded more than $3 million in grants to some 300 playwrights and theatre companies. More than 150 productions of EST/Sloan-developed plays have been mounted nationwide.

Every year the highlight of the EST/Sloan Project submission season is the Fall Artist Cultivation Event. At this eagerly anticipated event, a panel of scientists, science writers, and playwrights engages in a far-ranging and free-wheeling discussion with an audience of prospective playwrights about “What Makes a Great Play about Science?” 

The 2022 Fall Artist Cultivation Event will be virtual this year and take place on Thursday, December 2 at 8 PM. 

This virtual event will be held on Zoom and is free to attend for any playwright interested in developing a play about science or technology. Registration is required. Once registered, you will receive the event access link in your confirmation email. You can register here.

Applications for this year’s EST/Sloan commissions are currently open and will be accepted through January 15, 2022. You can view previous commission recipients on the EST/Sloan webpage.

Two related events culminate each EST/Sloan season:

1) The First Light Festival is a month-long series of readings and workshops that showcase plays in development, and

2) a full mainstage production of at least one work. Recent mainstage productions have included Behind the Sheet (2019) by Charly Evon Simpson on the enslaved women who as experimental victims launched the science of gynecology (a NY Times Critic’s Pick), BUMP by Chiara Atik (2018) on pregnancy and childbirth, SPILL (2017) by Leigh Fondakowski on the Deepwater Horizon disaster, Boy (2016) by Anna Ziegler on sexual identity, Please Continue (2016) by Frank Basloe on Stanley Milgram’s obedience experiments, Informed Consent (2015) by Deborah Zoe Laufer on scientific research and Alzheimer’s, Fast Company (2014) by Carla Ching on game theory and confidence games, Isaac’s Eye (2013) by Lucas Hnath on scientific method and rivalry, and Headstrong (2012) by Patrick Link on sports and concussions.

This year's Artist Cultivation Event panelists include:

Jad Abumrad (Photo: Lizzie Johnston)

Jad Abumrad is the host and creator of Radiolab, a public radio program broadcast on nearly 600 stations and downloaded more than 12 million times a month as a podcast. He employs his dual backgrounds as composer and journalist to create what’s been called “a new aesthetic” in broadcast journalism. He orchestrates dialogue, music, interviews, and sounds into compelling documentaries that draw listeners into investigations of otherwise intimidating topics, such as the nature of numbers, the evolution of altruism, or the legal foundation for the war on terror. Jad has won three George Foster Peabody Awards, and in 2011, he was honored as a MacArthur Fellow. He also created and hosted three seasons of More Perfect, a series about untold stories of the Supreme Court, which The New York Times called “. . . possibly the most mesmerizing podcast.” And in 2019, he co-created Dolly Parton’s America, a Peabody Award-winning nine-part series that explores a divided America through the life and music of one of its greatest icons.

Sam Chanse

Sam Chanse’s plays include Monument, or Four Sisters (A Sloth Play); Trigger; Fruiting Bodies; and What You Are Now (EST/Sloan’s 2022 Mainstage Production). Her work has recently been developed with The Civilians, Ensemble Studio Theatre, Ars Nova,  NAATCO, Magic Theatre, Ma-Yi, and the Lark, and is published by Kaya Press (Lydia’s Funeral Video) and TCG (The Kilroys List). Commissions include NAATCO (Out of Time), Workshop Theatre, and EST/Sloan Project.  She is a past fellow at MacDowell, the Lark Venturous Fund (Trigger), Cherry Lane Mentor Project (The Opportunities of Extinction), and Playwrights Realm (The Other Instinct), and an alum of New York Stage and Film’s inaugural NEXUS project, Ars Nova’s Play Group and the Civilians R&D Group. She has also received residencies from Sundance Theatre Institute, Djerassi, and SPACE at Ryder Farm.  A native New Yorker, she served for some years as artistic director of San Francisco-based Kearny Street Workshop. She is a writer on ABC’s The Good Doctor, and has taught at Columbia University, NYU, University of Rochester, and elsewhere. She is a member of the Ma-Yi Writers Lab, Dramatists Guild, and WGAE, and a resident playwright at New Dramatists.

Dr. Karine Gibbs (Photo: Adam Sings in the Timber)

Karine Gibbs is a Jamaican American microbiologist and immunologist and an Associate Professor in the Department of Plant and Microbial Biology at the University of California, Berkeley. Gibbs’ research merges the fields of sociomicrobiology and bacterial cell biology to explore how the bacterial pathogen Proteus mirabilis, a common gut bacterium which can become pathogenic and cause urinary tract infections, identifies self versus non-self. In 2013, Gibbs and her team were the first to sequence the genome of P. mirabilis BB2000, the model organism for studying self-recognition. In graduate school at Stanford University, Gibbs helped to pioneer the design of a novel tool that allowed for visualization of the movement of bacterial membrane proteins in real time. In 2020, Gibbs was recognized by Cell Press as one of the top 100 Inspiring Black Scientists in America.

Lucas Hnath (Photo: Rebecca Martinez)

Lucas Hnath is the author of Isaac’s Eye, which EST produced as the 2012 EST/Sloan Mainstage Production and which won the 2012 Whitfield Cook Award. More recently, Lucas Hnath received a 2017 Tony Award nomination for Best Play with A Doll’s House, Part 2, which garnered eight Tony nominations—the most of any play in the 2016-2017 season—and a Best Actress win for Laurie Metcalf as Nora. His other plays include Hillary and Clinton, The Thin Place, Red Speedo, The Christians, A Public Reading of an Unproduced Screenplay About the Death of Walt Disney, and Death Tax. He has been produced on Broadway at the John Golden Theatre, Off-Broadway at New York Theatre Workshop, Playwrights Horizons, Soho Rep, and Ensemble Studio Theatre. His plays have also premiered at the Humana Festival of New Plays, Victory Gardens, and South Coast Repertory. He is a New York Theatre Workshop Usual Suspect, a member of Ensemble Studio Theatre, and an alumnus of New Dramatists. Awards: Whiting Award, Guggenheim Fellowship, Kesselring Prize, Outer Critics Circle Award for Best New Play, Obie Award for Playwriting, Steinberg Playwright Award, and the Windham-Campbell Literary Prize.

Dr. Mandë Holford (Photo: DFinnin_AMNH)

Mandë Holford is an Associate Professor in Chemistry at Hunter College and CUNY-Graduate Center, with scientific appointments at The American Museum of Natural History and Weill Cornell Medicine. Her research, from mollusks to medicine, combines chemistry and biology to discover, characterize, and deliver novel peptides from venomous marine snails as tools for manipulating cellular physiology in pain and cancer. She is active in science education, advancing the public understanding of science, and science diplomacy. She co-founded Killer Snails, LLC, an award winning EdTech learning games company. Her honors include being named: a 2020 Sustainability Pioneer by the World Economic Forum, Breakthrough Women in Science by the Howard Hughes Medical Institute and NPR’s Science Friday, a Wings WorldQuest Women of Discovery fellow, an NSF CAREER awardee, and a fellow of the California Academy of Sciences. Her Ph.D. is from The Rockefeller University, USA.

This year’s moderator:

Rich Kelley

Rich Kelley has served as the Science Press Liaison for The EST/Sloan Project since 2009. He also contributes interviews and blog posts to the EST/Sloan blog and creates panels for post-performance talkbacks. A book publishing veteran, Rich is currently VP/Strategic Partner with Bridget Marmion Book Marketing, where he specializes in content development, email marketing, online advertising, SEO, social media coaching, and website optimization.